Hansel Laboratory Department of Pathology

Hansel Lab Research

Our lab is interested in identifying high-yield, targetable pathways in advanced bladder cancer, with a strong emphasis on mTOR signaling and novel downstream targets that are involved in cell motility and invasion. Our emphasis is on advanced bladder cancer, which currently has limited therapeutic options when conventional therapy fails.

We utilize both in vitro and xenograft model systems to test migration and invasion in bladder cancer. A unique aspect of our laboratory is the use of human bladder cancer specimens – both as primary cultures and ex vivo bladder wall cultures – to understand invasion in a “translationally relevant” context.

We have expanded on our mTOR signaling work to identify novel downstream targets of mTORC1 and mTORC2 complexes that influence migration and invasion of bladder cancer cells. We have also evaluated the novel microenvironment of bladder cancer to identify putative mediators of mTOR complex signaling in this model system.

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